POSITION SUMMARY
As a member of our Quantitative Metabolism team within ADME (Absorption, Distribution, Metabolism and Excretion) Sciences, you will help advance Pfizer’s small molecule portfolio from discovery through development.
You will shape fit-for-purpose ADME strategies, identify and mitigate disposition risks, and translate enzymology and ADME data into evidence-based recommendations that guide discovery and development project decisions. This includes owning scientific questions from hypothesis generation through experimental strategy, data generation and interpretation, risk assessment, and communication of clear recommendations to teams.
KEY RESPONSIBILITIES
Own the design, execution, and interpretation of fit-for-purpose enzymology studies that address key questions in clearance, disposition, in vitro-to-in vivo translation, and DDI risk.
Provide scientific ownership for key ADME risk assessments, such as determining whether clearance mechanisms, enzyme involvement, induction or inhibition liabilities are sufficiently understood to support project decisions.
Mentor scientists through experimental oversight, technical guidance, data review, and coaching that builds scientific independence.
Identifies capability gaps, and creates new options through technology, external networks, partnerships, or novel approaches
MINIMUM QUALIFICATIONS
Knowledge of enzymology/drug metabolism principles, such as enzyme kinetics, reaction phenotyping, drug-drug interactions, and pharmacokinetic predictions.
Experience independently leading complex ADME workstreams, integrating study design, data interpretation, and scientific recommendations that support project decision making and advance our predictive sciences.
Strong written and verbal communication skills, including experience preparing technical reports, project recommendations, presentations, or external scientific communications.
PREFERRED QUALIFICATIONS
Expertise in another ADME science discipline, such as biotransformation, transporters, or PBPK modeling.
Experience connecting mechanistic ADME findings to chemistry, translational sciences, clinical pharmacology, toxicology, regulatory strategy, or nonclinical study packages.
Record of improving assays, workflows, data quality, or technology implementation, including responsible use of common AI tools such as Microsoft Copilot to enhance problem solving and productivity.
Broader scientific impact through internal guidance, external publications, conference presentations, or ADME/DMPK best practices.
PHYSICAL/MENTAL REQUIREMENTS
Laboratory work, use of laboratory equipment, and adherence to safe laboratory practices
Occasional lifting
Mathematical calculations and complex data analysis
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
WORK LOCATION ASSIGNMENT: This is a lab based position requiring the colleague to work onsite 5 days a week. This is not a hybrid position.
The annual base salary for this position ranges from $106,000.00 to $176,600.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Research and Development